Hypertension-misattributed kidney disease in African Americans.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 23271482.
- Also identified by DOI 10.1038/ki.2012.369.
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Abstract
Lipkowitz et al. extend the African American Study of Kidney Disease and Hypertension to the level of genetic epidemiology, in a case-control study design. Analysis of genotypes at the APOL1 kidney disease risk region supports a paradigm shift in which genetic risk is proximate to both kidney disease and hypertension. The findings mandate urgency in clarifying mechanisms whereby APOL1 region risk variants interact with environmental triggers to cause progressive kidney disease accompanied by dangerous hypertension.
Medical subject headings
- Black or African American
- Apolipoproteins
- Genetic Variation
- Hypertension, Renal
- Kidney
- Lipoproteins, HDL
- Nephritis