Multiple aneurysms in a patient with aneurysms-osteoarthritis syndrome.

Martens, Thomas; Van Herzeele, Isabelle; De Ryck, Frederic; Renard, Marjolijn; De Paepe, Anne; François, Katrien; Vermassen, Frank; De Backer, Julie · Ann Thorac Surg · 2013

case_report · Level V

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Abstract

The aneurysms-osteoarthritis syndrome (AOS) was recently described and encompasses multiple aneurysms and tortuosity of the great arteries. Most patients have early-onset osteoarthritis. We report the diagnosis, treatment, and follow-up of a patient presenting with bilateral aneurysms of the common iliac arteries and an ascending aortic aneurysm. After proper surgical treatment, genetic studies revealed a causal mutation in the SMAD3 gene.

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