Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 23275608.
- Also identified by DOI 10.1093/infdis/jis777 and PMC identifier 3571441.
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Abstract
Over three-fourths of human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) have at least one herpesvirus detected in their semen, and cytomegalovirus (CMV) is the most prevalent. The presence of CMV is associated with higher T-cell immune activation and with HIV disease progression in treated and untreated individuals. In this study of 113 antiretroviral (ART)-naive HIV-infected MSM, we found that CMV replication in blood and semen was associated with higher levels of HIV DNA in peripheral blood mononuclear cells. These observations suggest that interventions aimed to reduce CMV replication and, thus, systemic immune activation could decrease the size of the latent HIV reservoir.
Medical subject headings
- Cytomegalovirus
- DNA, Viral
- HIV
- HIV Infections
- Leukocytes, Mononuclear
- Proviruses
- Semen