Modular 'click-in-emulsion' bone-targeted nanogels.
basic_science · Level V
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- Record sourced from PubMed, PMID 23280931.
- Also identified by DOI 10.1002/adma.201202881 and PMC identifier 3815631.
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Abstract
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.