Total synthesis of Septocylindrin B and C-terminus modified analogues.
basic_science · Level V
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- Record sourced from PubMed, PMID 23284749.
- Also identified by DOI 10.1371/journal.pone.0051708 and PMC identifier PMC3527430.
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Abstract
The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tested for their membrane perturbation properties by fluorescent dye leakage assay and for their antibacterial activity.