The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.
basic_science · Level V
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- Record sourced from PubMed, PMID 23285047.
- Also identified by DOI 10.1371/journal.pone.0052447 and PMC identifier PMC39005.
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Abstract
THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages.