Metabolic makeover for HSCs.
editorial · Level V
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- Record sourced from PubMed, PMID 23290130.
- Also identified by DOI 10.1016/j.stem.2012.12.005.
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Abstract
Hematopoietic stem cells (HSCs) must at times exit quiescence to divide and produce differentiated blood cells. In this issue of Cell Stem Cell, Takubo et al. (2013) and Yu et al. (2013) show that these opposing actions require distinct metabolic programs to meet the changing energy demands of self-renewing HSCs.