Keeping stem cells in check: a hippo balancing act.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23290131.
- Also identified by DOI 10.1016/j.stem.2012.12.004.
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Abstract
Knowing when to stop proliferation is crucial for any regenerative process. In a recent issue of Nature,Barry et al. (2012) report that the Hippo pathway component YAP negatively regulates Wnt signaling, thereby preventing stem cell overpopulation after a regenerative response in the intestine.