One-step photo synthesis of protein-drug nanoassemblies for drug delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23296632.
- Also identified by DOI 10.1002/adhm.201200285.
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Abstract
Upon controlled UV illumination, disulfide bonds in bovine α-lactalbumin (BLA) are selectively broken, leading to self-assembly of the BLA and doxorubicin (DOX) molecules into nanoparticles via hydrophobic interactions and intermolecular disulfide bonds. Such protein-drug nanoparticles have synergistic anticancer activity in vitro and tumor-homing specificity in vivo, which are of great potential for systemic drug delivery in cancer therapy.
Medical subject headings
- Antineoplastic Combined Chemotherapy Protocols
- Doxorubicin
- Lactalbumin
- Nanocapsules
- Neoplasms, Experimental
- Oleic Acid