Detection of paranasal ectopic adrenocorticotropic hormone-secreting pituitary adenoma by Ga-68-DOTANOC positron-emission tomography-computed tomography.
case_report · Level V
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- Record sourced from PubMed, PMID 23299948.
- Also identified by DOI 10.1002/lary.23867.
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Abstract
Ectopic adrenocorticotropic hormone (ACTH)-secreting tumors account for approximately 10% of Cushing's syndrome (CS). We present an extremely rare case of a patient with CS caused by an ectopic ACTH-secreting pituitary adenoma (EAPA) of the ethmoid sinus. The tumor was identified by positron-emission tomography-computed tomography (PET/CT) using the somatostatin receptor analogue Ga-68-DOTANOC. Transnasal endoscopic resection was performed and the patient showed significant clinical improvement with normalization of the endocrine pituitary axis. Immunostaining showed a somatostatin receptor 2 and 5-positive ACTH-producing adenoma. In patients with ectopic ACTH secretion, Ga-68-DOTANOC-PET/CT may play an important role in the localization of EAPA. Transnasal endoscopic resection is the therapy of choice.
Medical subject headings
- ACTH Syndrome, Ectopic
- ACTH-Secreting Pituitary Adenoma
- Adenoma
- Adrenocorticotropic Hormone
- Multimodal Imaging
- Organometallic Compounds
- Paranasal Sinus Neoplasms
- Positron-Emission Tomography
- Tomography, X-Ray Computed