Chapter 11: Genome-wide association studies.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23300413.
- Also identified by DOI 10.1371/journal.pcbi.1002822 and PMC identifier 3531285.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS.
Medical subject headings
- Genome-Wide Association Study