Lower motor neuron disease in a patient with autoantibodies against Gal(beta 1-3)GalNAc in gangliosides GM1 and GD1b: improvement following immunotherapy.
case_report · Level V
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Abstract
We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM1 detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD1b and Gal (beta 1-3) GalNAc.
Medical subject headings
- Antigens, Tumor-Associated, Carbohydrate
- Autoantibodies
- Disaccharides
- G(M1) Ganglioside
- Gangliosides
- Immunoglobulin M
- Immunotherapy
- Motor Neurons
- Neuromuscular Diseases