Microglia: scapegoat, saboteur, or something else?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23307732.
- Also identified by DOI 10.1126/science.1227901 and PMC identifier 4431634.
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Abstract
Microglia are resident immune cells in the brain and spinal cord. These cells provide immune surveillance and are mobilized in response to disparate diseases and injuries. Although microglial activation is often considered neurotoxic, microglia are essential defenders against many neurodegenerative diseases. It also seems increasingly likely that microglial dysfunction can underlie certain neurological diseases without an obvious immune component.
Medical subject headings
- Mental Disorders
- Microglia
- Neurodegenerative Diseases
- Neurogenic Inflammation
- Neuroimmunomodulation