Making muscle or mitochondria by selective splicing of PGC-1α.
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- Record sourced from PubMed, PMID 23312277.
- Also identified by DOI 10.1016/j.cmet.2012.12.008 and PMC identifier 3613141.
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Abstract
Endurance training induces the transcriptional coactivator PGC-1α in skeletal muscle, promoting mitochondrial biogenesis and skeletal muscle remodeling. In a recent issue of Cell, Ruas et al. (2012) show that resistance training regulates the splicing of a novel isoform of PGC-1α (PGC-1α4), which is sufficient to stimulate skeletal muscle hypertrophy.