Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23313553.
- Also identified by DOI 10.1016/j.cell.2012.10.054 and PMC identifier 3597350.
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Abstract
Cytosine methylation is involved in various biological processes such as silencing of transposable elements (TEs) and imprinting. Multiple pathways regulate DNA methylation in different sequence contexts, but the factors that regulate DNA methylation at a given site in the genome largely remain unknown. Here we have surveyed the methylomes of a comprehensive list of 86 Arabidopsis gene silencing mutants by generating single-nucleotide resolution maps of DNA methylation. We find that DNA methylation is site specifically regulated by different factors. Furthermore, we have identified additional regulators of DNA methylation. These data and analyses will serve as a comprehensive community resource for further understanding the control of DNA methylation patterning.
Medical subject headings
- Arabidopsis
- DNA Methylation
- Genome, Plant