C4 null genes in American whites and blacks with myositis.
case_control · Level III
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- Record sourced from PubMed, PMID 2332854.
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Abstract
The frequencies of C4A and C4B alleles were determined in 66 adults with myositis in relation to HLA class I and II. In whites with myositis, the C4A*Q0 allele occurred in 13/31 (47%) as compared to 25/101 (25%) normal controls (p = 0.08, relative risk = 2.7). Only 11/35 (31%) of black patients with myositis had a C4A*Q0 allele compared to 11/55 (20%) of controls (p = NS, RR = 1.8). Thus, the MHC class III genes do not appear to be the primary genetic risk factors for myositis in adults.
Medical subject headings
- Alleles
- Black People
- Complement C4
- Genes
- Myositis
- White People