Metastability of the folded states of globular proteins.
basic_science · Level V
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- Record sourced from PubMed, PMID 2333297.
- Also identified by PMC identifier 53934.
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Abstract
The possibility that several metastable minima exist in which the folded forms of a polypeptide chain have similar structural characteristics but different energies is suggested. The validity of this hypothesis is illustrated with the aid of simulation methods on a model protein that folds into a beta-barrel structure. Some implications of this hypothesis such as the existence of multiple pathways with intermediates for protein folding are discussed.
Medical subject headings
- Protein Conformation
- Proteins