Raman-on-chip device and detection fibres with fibre Bragg grating for analysis of solutions and particles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23344502.
- Also identified by DOI 10.1039/c2lc41169e.
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Abstract
An all-fibre based Raman-on-chip setup is introduced which enables analysis of solutions and trapped particles without microscopes or objectives. Beside the novel quartz microfluidic chip, innovative multi-core single-mode fibres with integrated fibre Bragg gratings are used for detection. The limit of quantitation is 7.5 mM for urea and 2.5 mM for nicotine with linear Raman spectroscopy. This is an improvement of more than two orders of magnitude compared with previous fibre-based microfluidic Raman detection schemes. Furthermore, our device was combined with optical traps to collect Raman-on-chip spectra of spherical polymer beads.
Medical subject headings
- Microfluidic Analytical Techniques
- Nicotine
- Spectrum Analysis, Raman
- Urea