Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23344543.
- Also identified by DOI 10.1038/nrc3449.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections. There are few effective treatments partly because the cell- and molecular-based mechanisms that contribute to the pathogenesis of this tumour type are poorly understood. This Review outlines pathogenic mechanisms that seem to be common to both viruses and which suggest innovative approaches to the prevention and treatment of HCC.
Medical subject headings
- Carcinoma, Hepatocellular
- Hepacivirus
- Hepatitis B virus
- Hepatitis B, Chronic
- Hepatitis C, Chronic
- Liver Neoplasms