Changes in the blood flow of the femoral artery by botulinum toxin A in rats.
basic_science · Level V
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- Record sourced from PubMed, PMID 23348394.
- Also identified by DOI 10.1097/SAP.0b013e31826eabe3.
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Abstract
We examined the changes in blood flow in the femoral artery caused by botulinum toxin A in rats. Blood flow was measured using laser Doppler flowmetry. We used male Sprague-Dawley-derived rats weighing between 350 and 400 g. The study was performed on 6 groups; each of them consisted of 30 rats (control and botulinum toxin A 0.5, 1, 2, 4, and 8 units). The laser Doppler flowmetry revealed that blood flow in the femoral artery increased by the third day in the groups injected with 1 or more units of botulinum toxin A. In the groups injected with 8 units of botulinum toxin A, we recognized an increase of blood flow from the second day. Our results suggest that botulinum toxin A is concerned in improving blood flow.
Medical subject headings
- Acetylcholine Release Inhibitors
- Botulinum Toxins, Type A
- Femoral Artery
- Regional Blood Flow