Glucocorticoids and osteocyte autophagy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23356984.
- Also identified by DOI 10.1016/j.bone.2013.01.034 and PMC identifier 3784314.
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Abstract
Glucocorticoids are used for the treatment of inflammatory and autoimmune diseases. While they are effective therapy, bone loss and incident fracture risk are high. While previous studies have found GC effects on both osteoclasts and osteoblasts, our work has focused on the effects of GCs on osteocytes. Osteocytes exposed to low dose GCs undergo autophagy while osteocytes exposed to high doses of GCs or for a prolonged period of time undergo apoptosis.
Medical subject headings
- Autophagy
- Glucocorticoids
- Osteocytes