Prediction of renal end points in chronic kidney disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23364584.
- Also identified by DOI 10.1038/ki.2012.418.
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Abstract
Estimated glomerular filtration rate and albuminuria are dominant clinical predictors of renal outcomes in chronic kidney disease. Wong and collaborators report that BMP-7 and transforming growth factor-β1 improve risk discrimination for renal end points in type 2 diabetes. However, to develop predictive models, clearly defined, clinically meaningful, validated end points must be used. End-stage renal disease and kidney transplantation remain the most definitive renal end points, whereas doubling of serum creatinine and death from renal disease lack rigor.
Medical subject headings
- Bone Morphogenetic Protein 7
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Kidney Failure, Chronic
- Transforming Growth Factor beta1