Evidence for inheritance of medullary sponge kidney.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 23364586.
- Also identified by DOI 10.1038/ki.2012.417.
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Abstract
Medullary sponge kidney (MSK) is associated with recurrent calcium stones. Gambaro's group evaluated the relatives of probands with MSK. When prior imaging was not available, they performed renal ultrasounds. They demonstrated familial clustering, providing the best evidence yet that MSK is a heritable disorder. Although a small proportion of MSK cases are associated with variants of glial cell-derived neurotrophic factor (GDNF), the genetic basis for most instances of MSK is not known.
Medical subject headings
- Medullary Sponge Kidney
- Penetrance