Induced pluripotent stem cells in cardiovascular drug discovery.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23371902.
- Also identified by DOI 10.1161/CIRCRESAHA.111.250266 and PMC identifier 3706265.
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Abstract
The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells exhibiting inherited traits and disorders. Use of these cells in high throughput analyses should broaden our insight into fundamental disease mechanisms and provide many benefits for patients, including new therapeutics and individually tailored therapies. Here we review recent progress in generating induced pluripotent stem cell-based models of cardiovascular disease and their multiple applications in drug development.
Medical subject headings
- Cardiovascular Agents
- Cardiovascular Diseases
- Drug Discovery
- High-Throughput Screening Assays
- Induced Pluripotent Stem Cells
- Myocytes, Cardiac