Unlatched BAX pairs for death.
basic_science · Level V
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- Record sourced from PubMed, PMID 23374333.
- Also identified by DOI 10.1016/j.cell.2013.01.018 and PMC identifier 3975071.
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Abstract
Self-interacting BAX proteins permeabilize outer mitochondrial membranes to trigger apoptotic cell death. Czabotar et al. present two revealing structures of BAX dimers: one dimer has an activator BH3 helix bound into its canonical cleft, and the other dimer exposes a planar hydrophobic face potentially critical for membrane interactions.