Conformational ensembles in GPCR activation.
basic_science · Level V
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- Record sourced from PubMed, PMID 23374334.
- Also identified by DOI 10.1016/j.cell.2013.01.025.
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Abstract
Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.