The role of telomeres in stem cells and cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23374336.
- Also identified by DOI 10.1016/j.cell.2013.01.010.
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Abstract
Telomere shortening impairs proliferation of transformed cells but also leads to cancer initiation by inducing chromosomal instability. Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis.
Medical subject headings
- Neoplasms
- Stem Cells
- Telomere