Genomes on the edge: programmed genome instability in ciliates.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23374338.
- Also identified by DOI 10.1016/j.cell.2013.01.005 and PMC identifier 3725814.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Ciliates are an ancient and diverse group of microbial eukaryotes that have emerged as powerful models for RNA-mediated epigenetic inheritance. They possess extensive sets of both tiny and long noncoding RNAs that, together with a suite of proteins that includes transposases, orchestrate a broad cascade of genome rearrangements during somatic nuclear development. This Review emphasizes three important themes: the remarkable role of RNA in shaping genome structure, recent discoveries that unify many deeply diverged ciliate genetic systems, and a surprising evolutionary "sign change" in the role of small RNAs between major species groups.
Medical subject headings
- Biological Evolution
- Ciliophora
- Genomic Instability
- RNA, Protozoan
- RNA, Untranslated