Effect of BN 52021, a platelet activating factor antagonist, on dithranol-induced inflammation.
basic_science · Level V
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Abstract
The effect of BN 52021, a selective platelet activating factor (PAF) antagonist was studied on dithranol-induced irritant dermatitis. Pretreatment of the skin with 0.45% BN 52021 ointment significantly suppressed the decrease in capillary resistance, rise in skin temperature and increase in skin-fold thickness produced by dithranol.
Medical subject headings
- Anthralin
- Dermatitis, Contact
- Diterpenes
- Lactones
- Platelet Activating Factor
- Skin