A neutral envelope-type nanoparticle containing pH-responsive and SS-cleavable lipid-like material as a carrier for plasmid DNA.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23386367.
- Also identified by DOI 10.1002/adhm.201200431.
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Abstract
SS-cleavable proton-activated lipid-like material (ssPalm) functions as a key element in a lipid nanoparticle in which pDNA is encapsulated. The ssPalm contains dual sensing motifs that can respond to the intracellular environment; a proton-sponge unit (tertiary amines) that functions in response to an acidic environment (endosome/lysosome), and disulfide bonding that can be cleaved in a reducing environment (cytosol).
Medical subject headings
- DNA
- Disulfides
- Nanoparticles
- Plasmids