Troponin: messenger or actor?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23391193.
- Also identified by DOI 10.1016/j.jacc.2012.11.024.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cardiac troponin (cTn) is a biomarker of myocardial damage. New generations of high-sensitivity assays find circulating cTn in virtually all subjects. Multiple studies in various populations and patient groups have found higher levels of cTn to be predictive of future heart failure. The author proposes that initial myocardial damage from various mechanisms may lead to anti-cTn antibodies that participate in ongoing myocardial damage that eventually results in heart failure.
Medical subject headings
- Autoantibodies
- Myocardium
- Troponin