Lipid metabolism greases the stem cell engine.
basic_science · Level V
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- Record sourced from PubMed, PMID 23395162.
- Also identified by DOI 10.1016/j.cmet.2013.01.010.
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Abstract
Metabolic plasticity is increasingly postulated to be vital in the transition between stemness maintenance and lineage specification. Knobloch et al. (2012) now demonstrate that regulation of lipogenesis by fatty acid synthase and Spot14-dependent malonyl-CoA supply determines the proliferative activity of resident neural stem cells, contributing to adult neurogenesis.