The Hunger Games: p53 regulates metabolism upon serine starvation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23395165.
- Also identified by DOI 10.1016/j.cmet.2013.01.012 and PMC identifier 3634368.
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Abstract
Cancer cells reprogram their metabolism to support a high proliferative rate. A new study shows that, upon serine starvation, the tumor suppressor p53 activates p21 to shift metabolic flux from purine biosynthesis to glutathione production, which enhances cellular proliferation and viability by combating ROS (Maddocks et al., 2013).