H2A.Z sets the stage in ESCs.
basic_science · Level V
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- Record sourced from PubMed, PMID 23395439.
- Also identified by DOI 10.1016/j.stem.2013.01.012.
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Abstract
ESCs undergo drastic changes in chromatin states during differentiation. Two recent papers in Cell (Li et al., 2012) and Cell Stem Cell (Hu et al., 2013) demonstrate that histone variant H2A.Z plays essential roles in this process by preconfiguring nucleosomes for depletion and recruiting transcription cofactors to cis-regulatory elements.