Crystal arthritis: Is HLAB genotyping the future of gout pharmacogenomics?
Level V
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- Record sourced from PubMed, PMID 23399693.
- Also identified by DOI 10.1038/nrrheum.2013.20 and PMC identifier 3899695.
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Abstract
Advances in pharmacogenomics have improved understanding of allopurinol hypersensitivity syndrome (AHS), and new research suggests HLA-B*5801 is a strong risk factor for this condition; in some populations, almost all patients who develop AHS carry this allele. This discovery could influence the treatment of gout, in particular, how allopurinol is used.
Medical subject headings
- Allopurinol
- Arthritis, Gouty
- Drug Eruptions
- HLA-B Antigens