Highly discriminating photorelease of anticancer drugs based on hypoxia activatable phototrigger conjugated chitosan nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23401259.
- Also identified by DOI 10.1002/adma.201204455.
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Abstract
An ultimately selective photorelease system of chitosan-nanoparticles is constructed. Only under unique aspects of tumor-hypoxia physiological conditions, the preliminary locked phototrigger is unlocked by biological reduction to enable the release of the caged drug either by visible light or two-photon near-IR (NIR) excitation. This approach provides a highly discriminating photorelease of anticancer drug to hypoxic tumor cells, but not to healthy normal cells.
Medical subject headings
- Antineoplastic Agents
- Cell Hypoxia
- Chitosan
- Drug Carriers
- Nanoparticles