Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23404693.
- Also identified by DOI 10.1002/adma.201204623 and PMC identifier 4138877.
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Abstract
Chlorin e6 conjugated gold nanostars (GNS-PEG-Ce6) are used to perform simultaneous photodynamic/plasmonic photothermal therapy (PDT/PPTT) upon single laser irradiation. The early-phase PDT effect is coordinated with the late-phase PPTT effect to obtain synergistic anticancer efficiency. The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo.
Medical subject headings
- Gold
- Lasers
- Metal Nanoparticles
- Photochemotherapy
- Photosensitizing Agents