Ovarian aging: breaking up is hard to fix.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 23408052.
- Also identified by DOI 10.1126/scitranslmed.3005579.
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Abstract
Accumulation of double-stranded DNA breaks and inhibition of DNA repair contributes to reproductive aging by diminishing ovarian reserves in mice and women.
Medical subject headings
- Aging
- BRCA1 Protein
- Cellular Senescence
- DNA Breaks, Double-Stranded
- DNA Repair
- Oocytes
- Ovary