Of fish and men: clonal lineage analysis identifies divergence in myocardial development.
basic_science · Level V
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- Record sourced from PubMed, PMID 23410876.
- Also identified by DOI 10.1161/CIRCRESAHA.113.300964 and PMC identifier 3600367.
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Abstract
A clear understanding of myocardial development is essential not only for understanding of the molecular basis of congenital heart disease and its prevention but also for successful regeneration after cardiac injury. A recent study employed a novel Cre/LoxP-based lineage tracing approach with a multi-color reporter in zebrafish to examine the fates of populations of developing cardiomyocytes. The results showed that a remarkably few number of clones of cardiomyocytes are involved in the formation of adult zebrafish heart. Furthermore, a striking difference in the mechanism of myocardial compaction was described involving the creation of a completely new layer of cortical myocardium.