A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23412111.
- Also identified by DOI 10.1039/c3lc50104c.
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Abstract
We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA "zigzag" channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.
Medical subject headings
- Antibodies, Monoclonal
- Lab-On-A-Chip Devices
- Polymethyl Methacrylate