GalaxyGemini: a web server for protein homo-oligomer structure prediction based on similarity.
basic_science · Level V
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- Record sourced from PubMed, PMID 23413437.
- Also identified by DOI 10.1093/bioinformatics/btt079.
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Abstract
SUMMARY: A large number of proteins function as homo-oligomers; therefore, predicting homo-oligomeric structure of proteins is of primary importance for understanding protein function at the molecular level. Here, we introduce a web server for prediction of protein homo-oligomer structure. The server takes a protein monomer structure as input and predicts its homo-oligomer structure from oligomer templates selected based on sequence and tertiary/quaternary structure similarity. Using protein model structures as input, the server shows clear improvement over the best methods of CASP9 in predicting oligomeric structures from amino acid sequences. AVAILABILITY: http://galaxy.seoklab.org/gemini. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Medical subject headings
- Protein Multimerization
- Software