The origins and drivers of insulin resistance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23415219.
- Also identified by DOI 10.1016/j.cell.2013.01.041.
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Abstract
Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which precedes the development of type 2 diabetes mellitus and is thus the driving force behind the emerging diabetes epidemic. The precise causes of insulin resistance are varied, and the relative importance of each is a matter of ongoing research. Here, we offer a Perspective on the heterogeneous etiology of insulin resistance, focusing in particular on the role of inflammation, lipid metabolism, and the gastrointestinal microbiota.
Medical subject headings
- Diabetes Mellitus, Type 2
- Insulin Resistance