Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23417835.
- Also identified by DOI 10.1002/adma.201205088 and PMC identifier 3757134.
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Abstract
Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.
Medical subject headings
- Cell Membrane
- Drug Carriers
- Mannose
- Nanostructures
- Transfection