Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers.
rct · Level II
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- Record sourced from PubMed, PMID 23418877.
- Also identified by DOI 10.1111/1471-0528.12173 and PMC identifier 3622799.
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Abstract
This study aims to confirm the feasibility of near-infrared (NIR) fluorescence imaging for sentinel lymph node (SLN) biopsy in vulvar cancer and to compare the tracer indocyanine green (ICG) bound to human serum albumin (HSA) versus ICG alone. Women received 99mTc-nanocolloid and patent blue for SLN detection. Subsequently, women randomly received ICG:HSA or ICG alone. In 24 women, 35 SLNs were intraoperatively detected. All SLNs detected were radioactive and NIR fluorescent and 27 (77%) were blue. No significant difference was found between ICG:HSA and ICG alone. This trial confirms the feasibility of NIR fluorescence imaging for SLN mapping in vulvar cancer.
Medical subject headings
- Image-Guided Biopsy
- Indocyanine Green
- Lymph Nodes
- Sentinel Lymph Node Biopsy
- Spectroscopy, Near-Infrared
- Vulvar Neoplasms