Gold-containing bioactive glasses: a solid-state synthesis to produce alternative biomaterials for bone implantations.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23427096.
- Also identified by DOI 10.1098/rsif.2012.1040 and PMC identifier 3627079.
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Abstract
A new melted bioactive system containing gold nanoparticles (AuNPs) was prepared exploiting a post-synthesis thermal treatment that allows one to modify crystal phases and nature, shape and distribution of the gold species in the glass-ceramic matrix as evidenced by UV-visible spectroscopy, transmission electron microscopy and powder X-ray diffraction analysis. In human MG-63 osteoblasts the presence of Au(n)(+) species caused an increase of lactate dehydrogenase leakage and malonyldialdehyde production, whereas Hench's Bioglass HAu-600-17 containing only AuNPs did not cause any effect. In addition, HAu-600-17 caused in vitro hydroxyapatite formation and an increase of specific surface area with a controlled release of gold species; this material is then suitable to be used as a model system for the controlled delivery of nanoparticles.
Medical subject headings
- Bone Substitutes
- Ceramics
- Gold
- Materials Testing
- Metal Nanoparticles
- Osteoblasts