A novel α-synuclein missense mutation in Parkinson disease.

Proukakis, Christos; Dudzik, Christopher G; Brier, Timothy; MacKay, Donna S; Cooper, J Mark; Millhauser, Glenn L; Houlden, Henry; Schapira, Anthony H · Neurology · 2013

case_report · Level V

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Abstract

Alpha-synuclein (SNCA) is central to the pathogenesis of Parkinson disease (PD), with 3 missense mutations reported to date. We report a novel mutation (p.H50Q) in a pathologically proven case.

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