How molecular testing can help (and hurt) in the workup of gliomas.
Level V
Where this comes from
- Record sourced from PubMed, PMID 23429363.
- Also identified by DOI 10.1309/AJCPFO8IIDNBIJ8Y and PMC identifier 4477533.
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Abstract
Advances in genetics research have greatly expanded our ability to accurately diagnose gliomas and provide more useful prognostic information. Herein specific examples are used to show how high-yield targets such as EGFR, 1p/19q, IDH1/2, MGMT, and BRAF can expand the power of the surgical neuropathologist. To avoid errors, however, the significance and controversies associated with each test must be thoroughly understood.
Medical subject headings
- Biomarkers, Tumor
- Brain Neoplasms
- Glioma