Zoom Zoom: racing CARs for multiple myeloma.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23444214.
- Also identified by DOI 10.1158/1078-0432.CCR-13-0168 and PMC identifier 3630266.
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Abstract
Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expand the possible indications for chimeric-antigen receptor (CAR)-T cells. B-cell maturation antigen (BCMA) is expressed only on mature B cells and plasma cells and promotes their survival. BCMA is a promising target for CAR-T cells in multiple myeloma.
Medical subject headings
- B-Cell Maturation Antigen
- Multiple Myeloma
- Receptors, Antigen, T-Cell
- T-Lymphocytes