IgG4: a tantalizing link between causes of membranous glomerulonephritis and systemic disease.
editorial · Level V
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- Record sourced from PubMed, PMID 23446252.
- Also identified by DOI 10.1038/ki.2012.454.
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Abstract
Alexander et al. give a detailed description of IgG4-related membranous glomerulonephritis (MGN). Their data delineate for the first time in IgG4-related disease (IgG4-RD) a second pattern of tissue injury occurring within the same organ. The paper highlights that MGN can occur alone or simultaneously with IgG4-related tubulointerstitial nephritis. Thus, it extends our understanding of IgG4-RD and illuminates potential pathways for new investigations into its pathophysiology.
Medical subject headings
- Glomerulonephritis, Membranous
- Immunoglobulin G
- Nephritis, Interstitial