Non-light-chain immunoglobulin amyloidosis: time to expand or refine the spectrum to include light+heavy chain amyloidosis?
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 23446254.
- Also identified by DOI 10.1038/ki.2012.433.
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Abstract
Among the various systemic amyloidoses, deposits derived from the immunoglobulin light chain (AL) account for 85% of cases. In this issue, Nasr et al. report 16 cases of renal heavy and light+heavy chain amyloidosis and compare them with renal light chain amyloidosis. While additional studies are needed to shed light on the heavy and light+heavy chain amyloidoses, several observations by the authors suggest important practical implications, including differences in clinical picture, prognosis and pathologic diagnosis.
Medical subject headings
- Amyloidosis
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Kidney Diseases